Whatever the term, I think the base cause is what created the "normal" biters. That's as far as evolution/whatever has taken humanity to this point in the story. The crash course in Intelligent Design is being perpetrated by either TOWTM or some power controlling him. The key questions that brings up are: a) is the root cause man-made or otherwise, b) how is the design of the Little Ones (and earlier special biters) being done, and c) who is doing all the work?
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