Yes I have heard Gabor Mate speak of Epigenetics. I would presume the Epigenetic effects occur after birth. But while genes are getting formed and programmed in Utero the mothers Environmental stimulus is also wiring information into the fetus. So the environment plays a role as soon as there is an Environment. The mothers stress levels, sugar levels, fat levels, and all kinds of other things affect the fetus' development. It's pretty amazing how much we know about behaviour and where criminal behaviour and addiction is derived.
To bring this chat back to Scratch, it seems rather obvious that her being tough and cruel affords her respect (or maybe just fear) from those around her. Either way, it's become a mode of survival for her, which is common for criminals. There are times where I see Scratch as this incredibly beautiful expression of feminine power, it's terrifying, but somehow beautiful at the same time.
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