Lets see... Hmmm... Well I am in a 22 story building in San Fransisco... Most of my co-workers are pretty lazy and only a few of them go to the gym with me. I(and a few others) are capable of out-running everyone else...so if some runners showed up they would eat all of my chubby co-workers before getting to me.

The "security" room two floors down has some batons and some tazers but I have only seen one security guard with a real gun... no I wouldn't be able to make it in time.

The quickest way down would be the elevator but that would be flooded quickly and if the electricity goes out, well, I wouldnt want to be in there- except that this building has back-up generators... so maybe.. No the elevators would still be flooded. As a weapon I would probably take the fire extinguisher that is 4 cubicles to my left (or was it 5?) and there is also my keyboard...

So I would take my chances falling down this 22 floor building and -after I land flat on my feet unhurt- I would have my keyboard as a back-up weapon and the fire extinuisher as my primary weapon. My plan is fool-proof!!