"monsters", so much reworking has been done to turn monsters into angst-ridden youths. Vampires are no longer the Nosferatu risen from the grave. They become essentially people with some minor advantages / disadvantages. Interview with a vampire, twilight, true blood. Can't go killing vampires wholesale, because they are people too and if they do get out of line it becomes a Law enforcement problem (either vampire or mundane).

Werewolves. Damn, dude. You cannot go around killing werewolves, they are human everyday of the month and supernatural threats a few nights a month. Hell, they might not even know.

Creature from the black lagoon, he probably showed up to stop toxic waste sewage from ruining the sea.

Zombies, well now, what do we have here. A ravenous hell-mouth. Nothing of the host remains, there is no cure and like the first terminator, they will not stop!

Something I have been playing with is what if it is more like a virus? What if the body could clear it in 10 to 14 days? What if unlike when they are turned, they REMEMBER everything they did while "sick"? What if like Ebola, there is an unknown reservoir and it comes back? Worse, what if it is like herpes or AIDS and never truly cleared from the host?