Well I attribute the cancer to the chemicals that Ink gave the Behemoths to make them like they were. Then he changed the cocktail for the Little/Numbered Ones. Then finally the next kind we haven't seen yet thanks to Saul.
Kind of funny if you think about it. Ink made it more complicated for himself then he needed to. Zombies will outlast survivors. All he had to really do was have the zombies gather all the resources into one spot and wait to trap anyone crazy enough to try to get them. Plus, if he could have the zombies dig tunnels all over LA, then I would just have them compromise the foundations of any buildings and make them fall down, or dig into the colony. Infiltrate while the survivors guard is down. Ink just focuses his energies in slightly the more complicated route.
The fact that Ink had so many plans and was executing them so quickly makes him one of the scariest villains I have ever seen.
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