There's no way Riley is gone/dead yet. She's too much of a fan favorite to just die off without directly effecting the main plot.

Datu is gonna die. He has to. He WAS the weakest character, the most vulnerable and now he's completely flipped conquering most of his fears. I see him going out as a choice and a future self sacrifice in a big way. It will be an emotional affair.

I don't know if the Randy story ends with just him subconsciously resenting Michael in zombie mode. I still don't understand why he was holding the protein juice.

I still think the shopping list is some kind of alchemy symbols. That the whole gas from ground zero is some archaic science project/borderline Egyptian witchcraft.

I also think Victor will get the chance to redeem himself with Michael.

Burt will have some sort of insight on their current events and help direct Tanya with her research. He must of ran into something important enough to inform them.