I'll hand it to you Bar you've got your ideal armory in order.
I've been able to take some very big Bull beef with a 22Mag mostly because I knew where to shoot em. The nice thing about a 22 is the scramble effect, not strong enough typically to go through two bones so it will bounce around in the skull. To that order, there was the odd beef that was rather resistant to my Mag and I needed a backup. I would like to reach for a .308 or a 7.62 DPMS, then to my shotgun and down to the .45 springfield XDM. Then to melee weapons.
Toothless grin